Correlation between tumor to liver SUV ratio and molecular subtypes of invasive breast carcinoma in PET CT

Abstract Background Breast cancer is known to be one of the most affecting women around globe and second common in general. In third worlds countries, breast cause death. Early diagnosis accurate follow-up these patients affect management. There are multiple prognostic factors important immunohistochemical molecular markers specimens including human epidermal growth factor, progesterone, estrogen receptors (HER2, PR, ER). cancer, HER2 positive subtype associated with a bad prognosis aggressive histological features, yet while following neoadjuvant chemotherapy, it achieves an increased pathological complete response rate. 18F-fluoro-2-deoxy- d -glucose positron emission tomography (FDG PET) has proved effective imaging technique for lymph node distant metastasis assessment, tumor staging, restaging recurrence, treatment response, follow-up. subtype, size, proliferation index, grade correlated (FDG) uptake. This study evaluates possible correlation between liver spleen (standardized uptake value) SUV max ratio four different subtypes pathologically proven primary cancer. Results Tumor (TLR, TSR) was significant parameter identification ( P value = 0.0005 0.014 respectively) luminal A 0.016 0.037 respectively). The specificity, sensitivity, area under receiver operating-characteristic curve (AUC) TLR parameters HER2-positive were 89.4%, 83.3%, 0.89, respectively. AUC TSR 57.9%, 100%, 0.83, Conclusions appeared valuable HER2- detection. thus, 18F-FDG PET/CT could beneficial tool prediction biological characteristics that help management patients.